Intracellular acidification-induced alkali metal cation/H+ exchange in human neutrophils.
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چکیده
منابع مشابه
Intracellular Acidification-induced Alkali Metal Cation/H + Exchange in Human Neutrophils
Pretreatment of isolated human neutrophils (resting pHi -~ 7.25 at pHo 7.40) with 30 mM NH4CI for 30 min leads to an intracellular acidification (pHi ~ 6.60) when the NH4CI prepulse is removed. Thereafter , in 140 mM Na + medium, pHi recovers exponentially with time (initial rate, -0 .12 pH/min) to reach the normal resting pHi by 2 0 rain, a process that is accomplished mainly, if not exclusive...
متن کاملIntracellular acidification-induced alkali metal cation/H+ exchange in human neutrophils
Pretreatment of isolated human neutrophils (resting pHi congruent to 7.25 at pHo 7.40) with 30 mM NH4Cl for 30 min leads to an intracellular acidification (pHi congruen to 6.60) when the NH4Cl prepulse is removed. Thereafter, in 140 mM Na+ medium, pHi recovers exponentially with time (initial rate, approximately 0.12 pH/min) to reach the normal resting pHi by approximately 20 min, a process tha...
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The intestinal absorption of many nutrients and drug molecules is mediated by ion-driven transport mechanisms in the intestinal enterocyte plasma membrane. Clearly, the establishment and maintenance of the driving forces - transepithelial ion gradients - are vital for maximum nutrient absorption. The purpose of this study was to determine the nature of intracellular pH (pH(i)) regulation in res...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1987
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.90.5.737